发明名称 |
Atherosclerotic plaque specific antigens, antibodies thereto, and uses thereof |
摘要 |
The subject invention provides a naturally occurring antigen indicative of the presence of atherosclerotic plaque. The subject invention provides a murine-human chimeric monoclonal antibody which specifically binds to an antigen indicative of the presence of atherosclerotic plaque; and methods and reagents involving the use of the murine-human chimeric monoclonal antibody. The subject invention provides a CDR-grafted antibody; and methods and reagents involving the use of the CDR-grafted antibody. The subject invention provides a surrogate antigen; methods and reagents involving the use of the surrogate antigen, preparation of the surrogate antigen, antibodies generated from the surrogate antigen.
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申请公布号 |
US5955584(A) |
申请公布日期 |
1999.09.21 |
申请号 |
US19930053451 |
申请日期 |
1993.04.26 |
申请人 |
CHARTER VENTURES |
发明人 |
DITLOW, CHARLES C.;CHEN, FRANCIS W.;CALENOFF, EMANUEL |
分类号 |
A61K38/00;A61K41/00;A61K47/48;C07C401/00;C07J9/00;C07J31/00;C07K14/47;C07K14/78;C07K16/18;C07K16/44;C07K16/46;G01N33/533;G01N33/543;G01N33/544;G01N33/564;G01N33/68;G01N33/92;(IPC1-7):C07K16/18;C12P21/08 |
主分类号 |
A61K38/00 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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