发明名称 |
New recombinant nucleic acid comprising promoter, gene and neuron restrictive silencer sequences to direct neuron-specific expression, e.g. for gene therapy of neurological disease |
摘要 |
New recombinant nucleic acid (I) comprises a promoter; one or more NRSE (neuron restrictive silencer element) sequences and a therapeutic gene (II), arranged such that (II) is controlled by the promoter and this, in turn, is controlled by the NRSE sequences. Independent claims are also included for the following: (a) vectors containing (I); (b) defective recombinant virus (A) containing a gene under control of a promoter and NRSE sequences; (c) cells containing (I), the vector or virus; (d) composition containing (I), the vector or virus; (e) chimeric promoter consisting of a ubiquitous promoter and one or more NRSE sequences. - ACTIVITY : Antineurodegenerative; anticancer; antioxidant. - MECHANISM OF ACTION : Selective suppression of gene expression in non-neuronal cells. -
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申请公布号 |
FR2774698(A1) |
申请公布日期 |
1999.08.13 |
申请号 |
FR19980001715 |
申请日期 |
1998.02.12 |
申请人 |
RHONE POULENC RORER SA |
发明人 |
KIEFER HELENE;MALLET JACQUES;MILLECAMPS STEPHANIE |
分类号 |
C12N15/09;A61K31/711;A61K35/76;A61K48/00;A61P25/28;C12N5/06;C12N5/10;C12N7/00;C12N15/12;C12N15/86;C12P21/02;C12R1/93;(IPC1-7):C12N15/12 |
主分类号 |
C12N15/09 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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