| 发明名称 |
SUBSTITUTED .BETA.-ALANINE DERIVATIVES AS CELL ADHESION INHIBITORS |
| 摘要 |
.beta.-Alanine derivatives of formula (I) are antagonists of VLA-4 and/or .alpha.4.beta.7, and as such are useful in the inhibition or prevention of cell adhesion and cell-adhesion mediated pathologies. These compounds may be formulated into pharmaceutical compositions and are suitable for use in the treatment of asthma, allergies, inflammation, multiple sclerosis, and other inflammatory and autoimmune disorders.
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| 申请公布号 |
CA2309341(A1) |
申请公布日期 |
1999.06.03 |
| 申请号 |
CA19982309341 |
申请日期 |
1998.11.24 |
| 申请人 |
MERCK & CO., INC. |
发明人 |
HAGMANN, WILLIAM K.;MUMFORD, RICHARD A.;DURETTE, PHILIPPE L.;KOPKA, IHOR E.;MILLS, SANDER G.;MACCOSS, MALCOLM;MAGRIOTIS, PLATO A. |
| 分类号 |
A61K31/401;A61K31/422;A61K31/4427;A61K31/443;A61K31/4439;A61K31/445;A61K31/4709;A61K31/472;A61K31/4725;A61K31/495;A61K31/506;A61P1/04;A61P3/10;A61P9/10;A61P11/06;A61P17/00;A61P17/06;A61P19/02;A61P21/00;A61P27/06;A61P27/16;A61P29/00;A61P37/06;A61P37/08;A61P43/00;C07D207/16;C07D207/48;C07D211/60;C07D211/96;C07D217/26;C07D241/04;C07D401/12;C07D403/12;C07D405/12;C07D413/12;(IPC1-7):C07D207/16;C07D211/34;A61K31/40;A61K31/42;A61K31/44;A61K31/47 |
主分类号 |
A61K31/401 |
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