发明名称 |
Antibodies which bind the G-CSF receptor extracelluar domain and methods of treatment |
摘要 |
PCT No. PCT/US95/01696 Sec. 371 Date Jan. 21, 1997 Sec. 102(e) Date Jan. 21, 1997 PCT Filed Feb. 8, 1995 PCT Pub. No. WO95/21864 PCT Pub. Date Aug. 17, 1995The invention relates to a composition comprising antibodies or binding portions thereof which bind to a naturally occurring or recombinant G-CSF receptor extracellular domain, and reduce tyrosine phosphorylation of a JAK molecule. The invention also relates to methods of using this composition for inhibiting or decreasing tyrosine phosphorylation of a JAK kinase and for inhibiting or decreasing G-CSF interaction with its receptor. Also described are antibodies which bind to a G-CSF receptor extracellular domain and which are produced by immunizing an animal with cells transfected with DNA encoding a G-CSF receptor.
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申请公布号 |
US5902584(A) |
申请公布日期 |
1999.05.11 |
申请号 |
US19970693241 |
申请日期 |
1997.01.21 |
申请人 |
LUDWIG INSTITUTE FOR CANCER RESEARCH |
发明人 |
NICHOLSON, SANDRA E.;LAYTON, JUDITH E.;WILKS, ANDREW F.;OATES, ANDREW C.;HARPUR, AILSA G. |
分类号 |
A61K38/00;A61P37/02;C07K16/28;(IPC1-7):A61K39/395;C07K16/00 |
主分类号 |
A61K38/00 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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