| 摘要 |
<p>Disclosed are nucleic acid constructs comprising a sequence encoding a plant viral coat protein (e.g. the S-peptide of CPMV) containing a foreign or heterologous peptide insert (e.g. an epitope for vaccine use) wherein the said coat protein has been modified such as to reduce its ability to effect nucleic acid packaging within viral particles. The modification is preferably at the C-terminus. Also disclosed are corresponding nucleic acid preparations, plus methods, processes and other materials (e.g. plants, virus particles, and compositions) based on the nucleic acids.</p> |
