Retroviral vector system for gene therapy

摘要

Retroviral vector system for gene transfer and expression in primary human T cells comprises (a) a retroviral vector containing cDNA corresponding to a therapeutic gene, a promoter selected from the SV40 immediate early promoter or the human IL-2 or MHC I promoter, and a selectable marker, and (b) a packaging cell line (i.e. a modified retroviral packaging line for enhanced transfer into primary human T lymphocytes).