IODINATED FATTY ACID ESTERS, IODINATED FATTY ACIDS AND DERIVATIVES THEREOF, PRODUCED BY IODOHYDRINATION USING ALKYLSILYLATED DERIVATIVES AND ALKALINE IODIDES, AND PHARMACOLOGICAL ACTIVITIES THEREOF.

摘要

Iodinated fatty acid esters, iodinated fatty acids and fluid pharmaceutical-grade stable derivatives thereof are produced by iodohydrination in an organic medium using alkylsilylated derivatives, e.g. trimethylsilyl chloride or trimethylchlorosilane, that react with an alkaline iodide such as sodium iodide, whereafter hydroiodic acid is formed in situ by exposure to water and the hydroiodic acid is reacted, e.g., with fatty acid esters and particularly rapeseed oil fatty acid methyl esters that may be used as a biofuel for gasoline engines to provide a low-cost product, and are used therapeutically, in particular for treating goitre linked to iodine deficiency.