发明名称 |
Parenchymal hepatocyte growth factors |
摘要 |
PCT No. PCT/JP94/00455 Sec. 371 Date Sep. 22, 1995 Sec. 102(e) Date Sep. 22, 1995 PCT Filed Mar. 22, 1994 PCT Pub. No. WO94/21678 PCT Pub. Date Sep. 29, 1994A novel parenchymal hepatocyte growth factor originating in a human or animal liver, having an estimated molecular weight according to nonreductive SDS-PAGE of about 63,000 to about 69,000, an estimated molecular weight according to reductive SDS-PAGE of about 32,000 to about 36,000 and an estimated molecular weight according to gel filtration of about 60 to about 70 Kd; and having an activity of effecting the growth of parenchymal hepatocyte has been obtained from the hemihepatectomized tissue. Furthermore, a gene coding for the above substance has been obtained from the mRNA of the above tissue and it has thus become possible to mass-produce the above substance.
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申请公布号 |
US5807711(A) |
申请公布日期 |
1998.09.15 |
申请号 |
US19950525505 |
申请日期 |
1995.09.22 |
申请人 |
TAISHO PHARMACEUTICAL CO., LTD. |
发明人 |
HARA, HIROSHI;YOSHIMURA, HIROMITSU;MATSUKI, YUMIKO;SHINDO, SAEKO;HANADA, KAZUNORI |
分类号 |
C07K14/475;C12N15/19;(IPC1-7):C07K1/32;C12N5/10;C12N15/18 |
主分类号 |
C07K14/475 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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