Enhancement of hematopoietic cells

摘要

The invention relates to a method for enhancing hematopoiesis by contacting hematopoietic stem or progenitor cells with a composition containing prolactin. Preferably the prolactin used is recombinant prolactin. Stimulation of hematopoesis can serve to replace hematopoietic cells as they become ablated because of a therapeutic drug or treatment. The enhancement can also function to recruit new or additional cell lineages to a depleted or poorly-functional repertoire of cells. The invention further relates to a method for treating an animal to improve hematopoiesis or prevent hematopoietic-suppresion by administering a pharmaceutically acceptable composition containing prolactin. The invention further relates to a composition comprising a cytokine that can enhance hematopoiesis and prolactin. The invention further relates to a composition comprising a therapeutic that can cause hematopoietic-suppresion and a prolactin.