Lysophosphatidic acid acyltransferase gene and its use

摘要

An assay for an inhibitor or activator of inflammation mediated via lysophosphatidic acid acyltransferase (LPAAT) which utilises recombinant human LPAAT. The recombinant human LPAAT is brought into contact with a candidate inhibitor or activator in the presence of a lysophosphatidic acid substrate and a fatty acid cofactor and the amount of LPAAT activity in the presence and absence of the inhibitor or activator is compared. Isolated LPAAT polypeptides, polynucleotides encoding LPAAT and vectors from which the LPAAT is expressed are provided.