发明名称 |
Bioactive substances K93-0711 I-1 and I-2 and process for production thereof |
摘要 |
Bioactive substances K93-0711 I-1 and I-2 having inhibitory action on IL-6 activity, are produced by culturing a microorganism belonging to the genus Streptomyces in a medium, whereby the bioactive substances K93-0711 I-1 and I-2 accumulate in the medium. These bioactive substances K93-0711 I-1 and I-2 are then isolated therefrom. The substances are effective for treatment of IL-6-involving diseases such as cancer cachexia, multiple myeloma and rheumatoid arthritis./!
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申请公布号 |
US5756320(A) |
申请公布日期 |
1998.05.26 |
申请号 |
US19970785767 |
申请日期 |
1997.01.21 |
申请人 |
THE KITASATO INSTITUTE |
发明人 |
OMURA, SATOSHI;KOMIYAMA, KANKI;HAYASHI, MASAHIKO;TAKAMATSU, SATOSHI |
分类号 |
C12P1/06;A61K35/74;A61P35/00;A61P43/00;C07D491/04;C07D491/048;C07G99/00;C12N1/20;C12P17/18;C12R1/465;(IPC1-7):C12P17/00;C12P17/16;C12P1/20;C07D209/56 |
主分类号 |
C12P1/06 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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