发明名称 |
5-Aminolevulinic acid producing microorganism, and process for producing it |
摘要 |
A microorganism that produces 5-aminolevulinic acid, wherein the microorganism has a 5-aminolevulinic acid dehydratase variant having a reduced inhibitor constant for a 5-aminolevulinic acid dehydratase inhibitor. A microorganism that produces 5-aminolevulinic acid, wherein the microorganism is a photosynthetic bacterium that produces 5-aminolevulinic acid without light irradiation. A process for producing 5-aminolevulinic acid comprising the step of culturing a microorganism that produces 5-aminolevulinic acid in a culture medium under at least one condition selected from the group consisting of (a) less than 1 ppm of dissolved oxygen concentration in the culture medium, (b) from -180 to 50 mV of oxidation-reduction potential in the culture medium, and (c) from 5x10<-9> to (KrM - 2x10<-8>) (mol of O2/m l .min.cell) of cellular respiration rate, wherein KrM represents the maximum cellular respiration rate when oxygen is supplied in an excess quantity. |
申请公布号 |
EP0718405(A3) |
申请公布日期 |
1998.05.20 |
申请号 |
EP19950120061 |
申请日期 |
1995.12.19 |
申请人 |
COSMO RESEARCH INSTITUTE;COSMO OIL COMPANY, LTD. |
发明人 |
WATANABE, KEITARO;NISHIKAWA, SEIJI;TANAKA, TOHRU;HOTTA, YASUSHI |
分类号 |
C12P13/00 |
主分类号 |
C12P13/00 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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