| 摘要 |
PROBLEM TO BE SOLVED: To obtain a novel polyene antibiotic substances 3874H1 to H6 which are produced by Streptomyces DSM11007 and is useful as an antifungal agent of a therapeutic agent for treatment of diseases relating to increased steroidal concentration. SOLUTION: This novel polyene antibiotic agent is produced by Streptomyces DSM11007 and comprises the following 6 substances: antibiotic substance 3874H1 is represented by formula I, has the molecular formula of C58 H86 N2 O18 and the molecular weight of 1099.3; the antibiotic substance 3874H2 is represented by formula II, has the molecular formula of C59 H88 N2 O18 and the molecular weight of 1113.3; the antibiotic substance 3874H3 is represented by formula III, has the molecular formula of C57 H87 N2 O18 and the molecular weight of 1074.3; the antibiotic substance 3874H4 is represented by formula IV, has the molecular formula of C58 H84 N2 O18 and the molecular weight of 1097.3; the antibiotic substance 3874H5 is represented by formula V, has the molecular formula of C57 H85 N2 O18 and the molecular weight of 1072.3. The agent is useful as an antifungal agent and for treatment of diseases relating to increased steroidalal concentration. These antibiotic substances are obtained by fermentation of Streptomyces DSM11007 or its mutant under appropriate conditions and isolating the products from the culture mixture, respectively. |
