This invention discloses a method for preparing a complex comprised of a VEGF Nucleic Acid Ligand and a Non-Immunogenic, High Molecular Weight Compound or Lipophilic Compound by identifying a VEGF Nucleic Acid Ligand by SELEX methodology and associating the VEGF Nucleic Acid Ligand with a Non-Immunogenic, High Molecular Weight Compound or Lipophilic Compound. The invention further discloses Complexes comprising one or more VEGF Nucleic Acid Ligands in association with a Non-Immunogenic, High Molecular Weight Compound or Lipophilic Compound. The invention further includes a Lipid construct comprising a VEGF Nucleic Acid Ligand or Complex and methods for making the same.
申请公布号
WO9818480(A1)
申请公布日期
1998.05.07
申请号
WO1997US18944
申请日期
1997.10.17
申请人
NEXSTAR PHARMACEUTICALS, INC.;JANJIC, NEBOJSA;GOLD, LARRY;SCHMIDT, PAUL, G.;VARGEESE, CHANDRA;WILLIS, MICHAEL
发明人
JANJIC, NEBOJSA;GOLD, LARRY;SCHMIDT, PAUL, G.;VARGEESE, CHANDRA;WILLIS, MICHAEL