摘要 |
PROBLEM TO BE SOLVED: To obtain a pharmaceutical agent capable of exhibiting modulation effect even on apoptosis by using a compound having an action to inhibit the dephosphorylation of cophylline as an active component. SOLUTION: This agent contains at least one kind of substance selected from a compound of the formula I and/or the formula II (R<1> is a 1-4C alkyl, a 3-5C cycloalkyl, etc.; R<2> is CF3 , O-CF3 , S-CF3 , OH, etc.; R<3> is a 1-4C alkyl, a halogen or H; X is CH or N atom) and/or its optical steric isomer and/or its physiologically permissible salt. The compound of the formula I or II is e.g. N-(4-trifluoromethylphenyl)-2-cyano-3-hydroxycrotonamide. The administration rate of the compound of the formula I and/or the formula II is preferably 2-250mg, especially 10-50mg. The agent is expected to be useful for the treatment of infarction, fit, transplantation, autoimmune diseases, etc.
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