发明名称 |
HYALURONIC DRUG DELIVERY SYSTEM |
摘要 |
Pharmaceutical compositions comprising a mixture of hyaluronic acid and liposomes. Preferably, the pharmaceutical compositions further include a pharmaceutically active substance such as cyclosporin A encapsulated in the liposomes. A method for preparing a pharmaceutical composition includes producing liposomes from phospholipids, preferably in the presence of a pharmaceutically active substance (most preferably cyclosporin A) to be encapsulated within the liposomes, and mixing the liposomes with hyaluronic acid. Pharmaceutical compositions of this invention are used, for example, to topically administer pharmaceutical agents effective to treat skin disorders by deposition of that agent in the dermis or sub-dermis while minimizing systemic circulation thereof. These compositions are also administered orally, parenterally and intrarectally.
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申请公布号 |
CA2266622(A1) |
申请公布日期 |
1998.04.02 |
申请号 |
CA19972266622 |
申请日期 |
1997.09.29 |
申请人 |
HYAL PHARMACEUTICAL CORPORATION |
发明人 |
BROWN, MARC BARRY;MARTIN, GARY PETER;MARRIOTT, CHRISTOPHER |
分类号 |
A61K9/00;A61K9/127;A61K38/13;A61K47/36;A61M36/14;(IPC1-7):A61K9/127;A61K48/00 |
主分类号 |
A61K9/00 |
代理机构 |
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代理人 |
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主权项 |
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