| 摘要 |
A benzoic acid compound represented by general formula (I) (wherein each symbol is as defined in the specification); an optical isomer or pharmaceutically acceptable salt thereof; a medicinal composition comprising the compound and pharmaceutically acceptable excipients; and a serotonin 4 receptor agonist, digestive function ameliorant, and digestive disease remedy, each containing the compound as the active ingredient. This compound has a selective agonism against serotonin 4 receptors and is useful as medicines for preventing and treating digestive diseases (e.g., delayed gastric excretion, maldigestion, tympanism, reflux esophagitis, abdominal unidentified complaint, pseudoileus, constipation, acute and chronic gastrites, gastroduodenal ulcer, Crohn's disease, nonulcer dyspepsia, ulcerous colitis, postgastrectomy syndrome, postanesthetic dysfunction of digestive system, gastroptosis, gastrointestinal disorder caused by diabetes or the like, and irritable bowel syndrome), central nervous system disturbances (e.g., schizophrenia, depression, anxiety, memory disorder, and dementia), cardiac function disorders (e.g., cardiac failure and myocardial ischemia), and urologic diseases (e.g., urinary obstruction, ureteral calculi, and urination difficulty accompanying prostatomegaly). |
