摘要 |
This invention concerns conjugates of transferrin, albumin and polyethylene glycol consisting of native or thiolated transferrin or albumin or of polyethylene glycol (MW between approx. 5000 and 200 000) with at least one HS-, HO- or H2N group and cytostatic compounds derived through maleinimide or N-hydroxysuccinimide ester-compounds, such as doxorubicene, daunorubicene, epirubicene, idarubicene, mitoxandrone, chlorambucil, melphalan, 5-fluorouracyl, 5'-desoxy-5-fluorouridene, thioguanine, methotrexate, paclitaxel, docetaxel, topotecan, 9-aminocamptothecene, etoposide, teniposide, mitopodoside, vinblastine, vincristine, vindesine, vinorelbin or a compound of general formula A, B, C or D, where n = 0-6, X = -NH2, -OH, -COOH, -O-CO-R-COR*, -NH-CO-R-COR*, where R is an aliphatic carbon chain with 1-6 carbon atoms or a substituted or unsubstitued phenylene group and R* H, phenyl, alkyl with 1-6 carbon atoms.
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申请人 |
KRATZ, FELIX, DR., 79232 MARCH, DE |
发明人 |
KRATZ, FELIX, DR., 79232 MARCH, DE |