Non-ulcerogenic analgesic/anti-inflammatory clonixin derivative

摘要

The clonixing derivative of formula (I), or 4-nitroxybutyl clonixate, is a novel non-steroidal analgesic-anti-inflammatory product that has an extraordinary good balance between high analgesic/anti-inflammatory activities and low ulcerogenic adverse effects, mainly as a consequence of a surprinsingly high anti-inflammatory activity (two times that of clonixic acid). Compound (I) is prepared by reaction of 4-chlorobutyl clonixate with silver nitrate in acetonitirle. 4-chlorobutyl clonixate is prepared by reaction of an alakaline clonixate with 1-bromo-4-chlorobutane in acetonitrile. 4-nitroxybutyl clonixate (I) is specially useful as an active principle for the treatment of pain and/or inflammation in mammals.