| 摘要 |
PCT No. PCT/SE92/00450 Sec. 371 Date Feb. 14, 1995 Sec. 102(e) Date Feb. 14, 1995 PCT Filed Jun. 18, 1992 PCT Pub. No. WO93/25566 PCT Pub. Date Dec. 23, 1993Deuterated nucleotide and nucleoside units are used to synthesize strands of RNA and DNA wherein one unit is non-deuterated, with adjacent units deuterated. The deuteration is sufficiently high in order that resonance from the deuterated units do not overlap with resonances from non-deuterated units in NMR-experiments. Thereby a "NMR"-window is created in the DNA or RNA strands, which can be beneficially used for advanced studies of structure versus biological activity in DNA and RNA.
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