POLYETHERESTER COPOLYMERS AS DRUG DELIVERY MATRICES

摘要

A composition for delivering a biologically active agent to host. The composition comprises a product including a biologically active agent encapsulated in a matrix comprising a copolymer, of a polyalkylene glycol and an aromatic polyester, such as a polyethylene glycol terephthalate/-polybutylene terephthalate copolymer. The polyether-ester copolymer protects the biologically active agent (including proteins, peptides, and small drug molecules) from degradation or denaturation and provides and essentially zero-order release.