METHOD FOR MEASURING PHYSICOCHEMICAL PROPERTIES OF TISSUES OR CELLS, METHOD FOR EXAMINING CHEMICALS, AND APPARATUS THEREFOR

摘要

A method of measuring the physical and chemical properties of tissue or cells and a device for the same is provided, with which the physical and chemical environment of the tissue or cells can be changed arbitrarily corresponding to experimental necessities. The device comprises a system (40) for keeping the physical and chemical environment surrounding the biological tissue or cells constant, a system (50) for arbitrarily changing the physical and chemical environment, observation systems (10) and (20) for observing the physical and chemical properties of the tissue or cells, and a system (30) for comparing the change of the physical and chemical properties of the tissue or cells before and after changing the physical and chemical environment. The observation system (10) is a potential measurement device for measuring the electrophysiological properties of the tissue or cells. This device comprises an integrated cell placement device (1) provided with a plurality of microelectrodes (11) on a substrate, a cell placement portion (6) for placing the tissue or cells on the microelectrodes (11), and a wiring pattern (12) for applying an electrical signal to the microelectrodes (11) and extracting an electrical signal from the microelectrodes (11).