摘要 |
The invention relates to novel spiro-2",4"-dioxo-oxazolidino-bisindole derivatives of formula (I), wherein: R1 means a methyl or formyl group; and R2 stands for a C1-4 alkyl, C3-4 alkenyl or halogenated C2-4 alkyl group, as well as acid addition salts thereof. Furthermore, the invention relates to the preparation of the above new compounds as well as pharmaceutical compositions containing the new compounds as active ingredients. The new compounds and compositions have a cytostatic antitumoral effect involving a new mechanism of action. In addition, these compounds show a calmodulin-liberator effect. |
申请人 |
MTA ENZIMOLOGIAI INTEZET;GRADIENS KFT. |
发明人 |
KEVE,TIBOR;OVADI,JUDIT;ACS,TIBOR;HLAVANDA,EMMA;KOVACS,JANOS;LEHOCZKY,ATTILA;OROSZ,FERENC;GROLMUSZNE DR.VERTESSY,BEATA;LILIOM,KAROLY;LOEW,PETER;MOLNAR,ATTILA;NURDISANY,ZOLTANNE |