| 发明名称 |
AMIDINOINDOLES, AMIDINOAZOLES, AND ANALOGS THEREOF AS INHIBITORS OF FACTOR XA AND OF THROMBIN |
| 摘要 |
The present application describes amidinoindoles, amidinoazoles, and analogs thereof of formula (I): wherein W, W1, W2, and W3 are selected from CH and N, provided that one of W1 and W2 is C(C(=NH)NH2) and at most two of W, W1, W2, and W3 are N and one of Ja and Jb is substituted by -(CH2)n-Z-A-B, which are useful as inhibitors of factor Xa or thrombin.
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| 申请公布号 |
CA2259573(A1) |
申请公布日期 |
1998.01.15 |
| 申请号 |
CA19972259573 |
申请日期 |
1997.06.30 |
| 申请人 |
DUPONT PHARMACEUTICALS COMPANY |
发明人 |
WEXLER, RUTH RICHMOND;HAN, QI;ROSSI, KAREN ANITA;DUFFY, DANIEL EMMETT;QUAN, MIMI LIFEN;DOMINGUEZ, CELIA;PARK, JEONGSOOK MARIA |
| 分类号 |
A61K31/404;A61K31/41;A61K31/416;A61K31/4184;A61K31/4439;A61K31/454;A61K31/496;A61P7/02;A61P43/00;C07D209/08;C07D209/14;C07D209/16;C07D209/18;C07D231/12;C07D231/56;C07D235/06;C07D307/79;C07D333/58;C07D401/06;C07D401/12;C07D403/06;C07D403/10;C07D403/12;C07D405/14;C07D471/04;(IPC1-7):C07D209/18;C07D403/00;C07D405/00;C07D409/00;C07D473/00;C07D475/00;C07D519/00;C07D453/02;C07D455/02;C07D487/04;C07D495/04;C07D491/048;C07D401/14;A61K31/33;A61K31/34;A61K31/38;A61K31/40;A61K31/415;A61K31/435;A61K31/44;A61K31/495;C07D333/54;C07D307/81 |
主分类号 |
A61K31/404 |
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