发明名称 Novel vitamin d analogues
摘要 The present invention relates to compounds of formula (I), in which formula X is hydrogen or hydroxy; R1 and R2, which may be the same or different, stand for hydrogen or a C1-C3 alkyl radical; or R1 and R2, taken together with the carbon atom bearing the group X, can form a C3-C6 carbocyclic ring, R3 stands for a C1-C3 alkyl radical, an aryl or an aralkyl radical, or for YR4, in which Y stands for the radicals -CO-S-, -CS-O- or -CS-S-, and R4 stands for a C1-C3 alkyl radical or an aryl or an aralkyl radical; Q is (CH2)n, n being 1-4. R1, R2 and Q independently may optionally be substituted with one or more fluorine atoms. The compounds show strong activity in inducing differentiation and inhibiting undesirable proliferation of certain cells as well as immunomodulating and antiinflammatory effects.
申请公布号 AU3025697(A) 申请公布日期 1998.01.05
申请号 AU19970030256 申请日期 1997.05.15
申请人 LEO PHARMACEUTICAL PRODUCTS LTD. A/S (LOVENS KEMISKE FABRIK PRO 发明人 CLAUS AAGE SVENSGAARD BRETTING
分类号 A61K31/00;A61K31/59;A61K31/593;A61P3/00;A61P3/10;A61P9/00;A61P9/12;A61P13/00;A61P13/12;A61P17/00;A61P17/02;A61P17/06;A61P17/10;A61P17/14;A61P19/00;A61P19/02;A61P19/10;A61P25/00;A61P25/28;A61P29/00;A61P31/00;A61P31/18;A61P35/00;A61P37/00;A61P37/02;A61P37/06;A61P43/00;C07C401/00 主分类号 A61K31/00
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