BIS-ORTHO-SUBSTITUTED BENZOYLGUANIDINES, PROCESSES FOR THEIR PREPARATION, THEIR USE AS A MEDICAMENT OR DIAGNOSTIC, AND MEDICAMENT COMPRISING THEM

摘要

Bis-ortho-substituted benzoylguanidines, processes for their preparation, their use as a medicament or diagnostic, and medicament containing them Bis-ortho-substituted benzoylguanidines of the formula I <IMG> I in which R(1) to R(5) have the meanings indicated in the claims, are suitable asantiarrhythmic pharmaceuticals having a cardioprotective component for infarct prophylaxis and infarct treatment, and for the treatment of angina pectoris. They also inhibit in a preventive manner the pathophysiological processes in theformation of ischemically induced damage, in particular in the elicitation of ischemically induced cardiac arrhythmias.