| 摘要 |
<p>This invention provides a method of contraception which comprises administering to a female of child bearing age for 23-25 consecutive days, a first phase combination of a progestin at a daily dosage equivalent in progestational activity to 40-125 mu g levonorgestrel and an estrogen at a daily dosage equivalent in estrogenic activity to 10-15 mu g ethinyl estradiol for 9-13 days beginning on day 1 of the menstrual cycle, wherein the same dosage of the progestin and estrogen combination is administered in each of the 9-13 days, a second phase combination of a progestin at a daily dosage equivalent in progestational activity to 40-125 mu g levonorgestrel and an estrogen at a daily dosage equivalent in estrogenic activity to 10-20 mu g ethinyl estradiol, for 11-15 days beginning on the day immediately following the last day of administration of the first phase combination, wherein the same dosage of the progestin and estrogen combination is administered in each of the 11-15 days, and an estrogen phase estrogen at a daily dosage equivalent in estrogenic activity to 10-20 mu g ethinyl estradiol, for 3-5 days beginning on the day immediately following the last day of administration of the third phase combination, wherein the same dosage of the estrogen is administered in each of the 3-5 days, provided that the daily dosage of second phase progestin is greater than the daily dosage of the first phase progestin and that the daily dosage of the second phase estrogen is greater than or equal to the daily dosage of the first phase estrogen.</p> |
