Di-and tri-peptide mimetic compounds for Parkinson's disease
摘要
A series of di- and tri-peptide mimetic dopamine prodrugs are synthesized in which D-phenylglycine or D-p-hydroxyphenylglycine is attached as tools for delivery of L-dopa through the intestine via the intestinal dipeptide-mediated carrier transport system. These compounds are found useful as an active ingredient for the treatment of Parkinson's disease.
申请公布号
US5686423(A)
申请公布日期
1997.11.11
申请号
US19960602361
申请日期
1996.02.16
申请人
DEPARTMENT OF HEALTH, THE EXECUTIVE YUAN, REPUBLIC OF CHINA
发明人
WANG, HUI-PO;LEE, JIA-SHUAI;TSAI, MING-CHENG;LU, HSIAO-HWA;HU, OLIVER YOA-PU;LUO, WEN-LIN