发明名称 |
Inhibition of tumor necrosis factor by retinoic acid |
摘要 |
A novel method of inhibiting production of two important mediators of cellular function, tumor necrosis factor and nitric oxide, and treating a pathophysiological state characterized by an undesirable production or level of tumor necrosis factor or nitric acid. The methods of the present invention employ retinoic acid compounds. The most preferred retinoic acid is all-trans-retinoic acid. Also provided is a method of inhibiting tumor necrosis factor receptors using retinoic acid-like compounds.
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申请公布号 |
US5658949(A) |
申请公布日期 |
1997.08.19 |
申请号 |
US19940346626 |
申请日期 |
1994.11.30 |
申请人 |
RESEARCH DEVELOPMENT FOUNDATION |
发明人 |
AGGARWAL, BHARAT B. |
分类号 |
A61K31/19;A61K31/07;A61K31/20;A61K31/203;A61P3/00;A61P3/02;A61P9/00;A61P19/02;A61P25/00;A61P29/00;A61P31/04;A61P33/06;A61P35/00;A61P37/00;A61P37/06;A61P43/00;(IPC1-7):A61K31/445 |
主分类号 |
A61K31/19 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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