发明名称 |
Strains of Escherichia coli which produce isoleucine or valine and a method for their production |
摘要 |
A method for constructing microorganism strains which produce amino acids comprising: combining in one bacterial genome (a) a mutation affecting the aminoacyl-tRNA synthetase corresponding to the selected amino acid, conferring cells auxotrophy which cannot be fully suppressed by addition of usual concentration this amino acid into the culture medium and (b) a mutation which destroys the negative regulation of selected amino acid biosynthesis to yield a strain capable of increased production of the selected amino acid. Strains producing isoleucine and valine. Methods to produce isoleucine and valine by culturing those strains.
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申请公布号 |
US5658766(A) |
申请公布日期 |
1997.08.19 |
申请号 |
US19960605552 |
申请日期 |
1996.02.20 |
申请人 |
AJINOMOTO CO., INC. |
发明人 |
LIVSHITS, VITALY ARKADIEVICH;DEBABOV, VLADIMIR GEORGIEVICH;FEDOROVVA, AAVEILOVA OKSAUA;PAVLOVVA, ZAKATAEVA NATALYA;SHAKULOV, RUSTEM SAIDOVICH;BACHINA, TATYANA ALEXANDROVNA;KHURGES, EVGENY MOISEEVICH |
分类号 |
C12P13/06;C12P13/08;(IPC1-7):C12P13/08 |
主分类号 |
C12P13/06 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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