| 发明名称 |
USE OF A THEXAPHYRIN IN THE PREPARATION OF A MEDICAMENT FOR USE WITH A CHEMOTHERAPEUTIC AGENT IN CANCER CHEMOSENSITIZATION |
| 摘要 |
Methods for cancer chemosensitization are provided. Texaphyrins are new chemosensitizers for enhancing the cytotoxicity of chemotherapeutic agents. The enhancement appears to be P-glycoprotein-independent since texaphyrins are effective in both a P-glycoprotein-expressing and a P-glycoprotein-nonexpressing cell line. Methods are provided for the treatment of cancers such as leukemia, lymphoma, carcinoma, and sarcoma using a texaphyrin as a chemosensitizer.
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| 申请公布号 |
WO9726915(A1) |
申请公布日期 |
1997.07.31 |
| 申请号 |
WO1997US00907 |
申请日期 |
1997.01.23 |
| 申请人 |
PHARMACYCLICS, INC.;MILLER, RICHARD, A.;YOUNG, STUART, W. |
发明人 |
MILLER, RICHARD, A.;YOUNG, STUART, W. |
| 分类号 |
C07D487/22;A61K31/00;A61K31/40;A61K31/555;A61K31/675;A61K33/24;A61K38/14;A61K41/00;A61P35/00;A61P35/02;A61P43/00;(IPC1-7):A61K41/00 |
主分类号 |
C07D487/22 |
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