| 摘要 |
PROBLEM TO BE SOLVED: To obtain a uzedicine useful as an antitumor agent and expected as an antitumor medicine having high safety and little side effect by compounding a specific naphthalene carboxylic acid derivative obtained from propolis or its salt as an active component. SOLUTION: This medicine contains 1,2,3,4,4a,7,8,8a-octahydro-1,4a,-5- trimethyl-1-(3-methyl-5-oxo-3-pentenyl)-2-naphthalene carboxylic acid of the formula or its salt as an active component. A compound of the formula is preferably obtained by a new method consisting of the extraction and purification from propolis. The below-mentioned processes are preferable for this purpose. At first, the solvent of an ethanol extract of propolis is removed by evaporation. The residue is extracted with a mixed solution of water and ethyl acetate, and subsequently the residue of the obtained ethyl acetate extract is extracted with methanol. The extract is purified serially with liquid chromatography using a reverse phase column, liquid chromatography using a absorption column and liquid chromatography using a molecular sieve column. |
