NEW FORM OF AMPHIREGULIN, METHODS FOR PRODUCING AND USING THE SAME AND COMPOSITIONS COMPRISING THE SAME

摘要

The present information relates to the discovery of a new form of amphiregulin, referred to as AR97-187. The new form differs from the hitherto described amphiregulin forms in that it contains 4 additional amino acids at its N-terminal end. It also differs from already described forms with respect to its interaction with heparin in that its biological activity is only marginally reduced in the presence of heparin. Possibly, AR97-187 is produced by differentiating keratinocytes. AR97-187 is of therapeutical interest for the treatment of a variety of conditions, including wound healing, skin disorders and cancer.