| 摘要 |
<p>A protected 4'-demethyl-4-epipodophyllotoxin is reacted with a protected glucose derivative in a non-halogen type organic solvent in a 0.1 to 7-fold-part by volume based on 1 part by weight of the protected 4'demethyl-4-epipodophyllotoxin to give an etoposide derivative of formula (3) which is protected at its functional groups: <CHEM> wherein each of R1 and R2 each is a protective group for hydroxy, if necessary, followed by removal of these protective groups. By use of the non-halogen type organic solvent in lieu of any harmful halogen type solvent, formation of undesirable by-products can be minimized so that the etoposides can be obtained in a high yield and high purity.</p> |
