发明名称 |
PHYSICAL TRAPPING TYPE POLYMERIC MICELLE DRUG PREPARATION |
摘要 |
The present invention relates to drug carriers composed of a block copolymer having hydrophilic and hydrophobic segments, a polymeric micelle type drug comprising hydrophobic drugs trapped by physical treatments in said drug carrier and methods for trapping hydrophobic drugs in the drug carrier. The drugs carrier composed of the block copolymer according to the invention forms a stable polymeric micelle structure with which hydrophobic drugs can be incorporated very efficiently via physical trapping. It was found that the incorporated drug is stably maintained in micelles even in the presence of serum. In addition, a drug difficult to administer into the living body owing to sparing water-solubility for its high hydrophobicity can be administered in the form of polymeric micelle drug. |
申请公布号 |
CA2104045(C) |
申请公布日期 |
1997.02.04 |
申请号 |
CA19932104045 |
申请日期 |
1993.08.13 |
申请人 |
RESEARCH DEVELOPMENT CORPORATION OF JAPAN |
发明人 |
YOKOYAMA, MASAYUKI;SAKURAI, YASUHISA;OKANO, TERUO;KATAOKA, KAZUNORI |
分类号 |
A61K9/00;A61K9/107;A61K9/51;A61K47/34;A61K47/48;C08G69/10;(IPC1-7):A61K9/10;A61K31/71;A61K31/405 |
主分类号 |
A61K9/00 |
代理机构 |
|
代理人 |
|
主权项 |
|
地址 |
|