| 摘要 |
<p>The present invention relates to a new protein, GTBP (Guanine Thymine Binding Protein), that binds to G/T DNA mismatches to mediate repair of genetic information, to methods for detection of this protein, to the nucleotidic sequence encoding this protein and to processes for obtaining the above-mentioned protein using genetic engineering techniques. Furthermore, the present invention has as its object the detection in tumor tissues of the mutant GTBP gene in order to prevent and provide rapid diagnosis of human colorectal tumor forms. The figure shows the absence of GTBP-specific activity in cells obtained from human colorectal tumors.</p> |
