| 摘要 |
Benzoylguanidines of the formula I <IMAGE> with R(1) equal to R(4)-SOm or R(5)R(6)N-SO2- with R(4) and R(5) equal to alk(en)yl, -CnH2n-R(7), and with R(7) equal to cycloalkyl or phenyl, where R(5) can also mean H, R(6) equals H or C1-C4-alkyl, R(2) is hydrogen, (cyclo)alk(en)(yn)yl, aryl and hetaryl R(3) is defined as R(2), and their pharmaceutically tolerated salts, are described. Compounds I are obtained by reacting compounds of the formula II <IMAGE> with guanidine, in which L is a leaving group which can easily undergo nuclophilic substitution. Compounds I are outstandingly suitable as antiarrhythmic drugs with cardioprotective component for the treatment and prophylaxis of infarct and for treating angina pectoris, and they also greatly reduce preventively the pathophysiological processes in the development of ischaemia-induced damage. Furthermore, I are distinguished by a potent inhibitory action on cell proliferation. They can thus be used as antiatherosclerotics, remedies for the late complications of diabetes, cancers, fibrotic disorders such as pulmonary, hepatic or renal fibrosis. They are effective inhibitors of the cellular sodium-proton antiporter (Na<+>/H<+> exchanger).
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