| 摘要 |
<p>A DNA virus vector, such as, for example, an adenoviral vector which includes at least one DNA sequence encoding at least one agent capable of providing for the inhibition, prevention, or destruction of the growth of tumor cells, such as a negative selective marker (e.g., Herpes Simplex Virus thymidine kinase), and a liver tumor cell specific promoter (e.g., the alphafetoprotein promoter) controlling the at least one DNA sequence encoding the at least one agent. Such a vector may transduce hepatocellular carcinoma cells in a host, whereby such cells are killed upon the administration of an interaction agent or prodrug (e.g., gancyclovir) to a host.</p> |
