发明名称 |
ARTERIOVENOUS AND VENOUS GRAFT TREATMENTS: METHODS AND COMPOSITIONS |
摘要 |
A method and compounds are provided for inhibiting the synthesis of extracellular matrix proteins. Compounds of the invention comprise oligonucleotides specific for nuclear proto-oncogenes. Preferably, oligonucleotides of the invention are selected from the group consisting of c-myc and c-myb and are locally administered. The invention finds use in the treatment of a variety of disorders, including sclerotic disorders and restenosis, associated with the inappropriate synthesis of extracellular matrix proteins, particularly collagen.
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申请公布号 |
WO9632966(A1) |
申请公布日期 |
1996.10.24 |
申请号 |
WO1996US05334 |
申请日期 |
1996.04.19 |
申请人 |
THOMAS JEFFERSON UNIVERSITY;ZALEWSKI, ANDREW;SHI, YI |
发明人 |
ZALEWSKI, ANDREW;SHI, YI |
分类号 |
C12N15/09;A61K31/70;A61K31/715;A61K38/00;A61K48/00;A61P9/00;A61P9/14;A61P11/00;A61P17/00;A61P29/00;A61P35/00;A61P43/00;C07H21/00;C07H21/04;C12N5/10;C12N5/22;C12N15/113;(IPC1-7):A61K48/00 |
主分类号 |
C12N15/09 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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