发明名称 |
Neues Verfahren zur Herstellung von 20-Oxo, 17-Alpha, 21-Dihydroxy Derivaten von Pregnan und neue Zwischenprodukte dafür |
摘要 |
<p>A process for the preparation of a compound of the formula <IMAGE> I wherein R1 is selected from the group consisting of hydrogen, alkyl of 1 to 4 carbon atoms optionally substituted by halogen or a nitrogen or oxygen function and alkenyl and alkynyl of 2 to 4 carbon atoms, R2 is alkyl of 1 to 4 carbon atoms and the A, B, C and D rings are optionally substituted by at least one member of the group consisting of optionally protected -OH or =0, halogen, alkyl and alkoxy of 1 to 4 carbon atoms and alkenyl and alkynyl of 2 to 4 carbon atoms comprising reacting a compound of the formula <IMAGE> II wherein R1 and R2 and the A, B, C and D rings are defined as above with an oxidizing agent in the presence of water and an at least partially water-miscible solvent to obtain a compound of the formula <IMAGE> III wherein R1 and R2 and the A, B, C and D rings are defined as above, subjecting the latter to a solvolysis in a basic or acidic media and optionally subjecting the product to a deprotection reaction of any protected -OH or =0 groups to obtain the compound of formula I and novel intermediates.</p> |
申请公布号 |
DE69213680(D1) |
申请公布日期 |
1996.10.17 |
申请号 |
DE1992613680 |
申请日期 |
1992.11.05 |
申请人 |
ROUSSEL-UCLAF, ROMAINVILLE, FR |
发明人 |
BUENDIA, JEAN, F-94170 LE PERREUX SUR MARNE, FR;VIVAT, MICHEL, F-77400 LAGNY SUR MARNE, FR |
分类号 |
A61K31/57;C07J5/00;C07J7/00;C07J41/00;(IPC1-7):C07J5/00 |
主分类号 |
A61K31/57 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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