Inclusion complexes with silybinin, their preparation and pharmaceutical compositions containing them

摘要

The invention relates to novel inclusion complexes of Silybinin with a cyclodextrin selected from the group consisting of alpha -, beta - and gamma -cyclodextrin and a suitable derivative thereof and to the method for the preparation thereof. The novel inclusion complexes of Silybinin showed a highly improved bioavailability in comparison to Silybinin which makes them particularly interesting in the treatment of various hepatotoxic conditions.