| 摘要 |
The invention concerns novel 17-difluoromethylene-oestratrienes of general formula (I), in which: R1 is a hydrogen atom or a C1-C10 alkyl group; R5 is a methyl or ethyl group; R2 is a hydrogen atom or an .alpha.- or .beta.-position C1-C10 alkyl group; R3 is a hydrogen atom or C1-C10 alkyloxy group; R4 is an .alpha.- or .beta.-position hydrogen atom; A, B, C, D, E and G each stand for a hydrogen atom; and optionnaly at least one of the substituent pairs G and R2, R2 and R4, R4 and A, A and R3, B and D, D and E represent a double bond. The novel compounds have antioxidant and vasculoprotective properties not previously noted in steroids and are suitable for use in the production of pharmaceutical preparations.
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