GENE TRANSFER FOR TREATING A CONNECTIVE TISSUE OF A MAMMALIAN HOST

摘要

The subject invention concerns a method of introducing at least one gene encoding a product into at least one cell of a connective tissue of a mammalian host for use in treating the mammalian host including employing recombinant techniques to produce a DNA vector molecule which contains the gene encoding for the product and infecting the connective cell of the mammalian host using the DNA vector molecule using the gene coding for the product. A method is provided for introducing at least one gene encoding a product into at least one cell of a connective tissue of a mammalian host employing non-viral means. A method to produce an animal model for the study of connective tissue pathology is also disclosed. Additionnally, this invention provides a method of using in vivo a gene encoding an extracellular interleukin-1 binding domain of an interleukin-1 receptor.