| 摘要 |
FIELD: vitamins. SUBSTANCE: invention relates to compounds 1,25-dihydroxy-16-en-24-oxocholecalciferol and 1,24,25-trihydroxy-16-en-cholecalciferol that stimulate differentiation of cells HL-60. Compounds were synthesized by perfusion of 1,25-dihydroxy-16-en-cholecalciferol in rat kidney, perfusate extraction and extraction of 1,25-dihydroxy-16-en-24-oxocholecalciferol and 1,24,25-trihydroxy-16-en-cholecalciferol. These compounds can be used for treatment oncogenic diseases (leukemia), they decrease human keratinocyte proliferation and therefore they can be used for treatment of hyperproliferative skin diseases, for example, psoriasis. EFFECT: improved method of preparing, enhanced effectiveness of compounds. |
