COMPOSITION FOR INHIBITING INTIMAL HYPERPLASIA USING PDGF ANTAGONISTS AND HEPARIN

摘要

Methods for inhibiting intimal hyperplasia in the vasculature of mammals, including primates, are disclosed. The methods comprise coordinately administering to the mammal a PDGF antagonist and heparin. The antagonist can be a non-peptidic antagonist or an anti-PDGF receptor antibody, such as an anti-PDGF-alpha receptor antibody or an anti-PDGF-beta receptor antibody. The methods are useful in reducing intimal hyperplasia due to, for example, vascular injuries resulting from angioplasty, endarterectomy, reduction atherectomy or anastomosis of a vascular graft.