发明名称 |
Methods and devices for immunizing a host to tumor-associated antigens through administration of naked polynucleotides which encode tumor-associated antigenic peptides |
摘要 |
The invention is directed to methods for introducing biologically active peptides into a host by administration of polynucleotides which operatively encode for the peptide of interest. In a preferred embodiment of the invention, a host who has been identified as having a tumor bearing at least one tumor-associated antigen is the recipient of a polynucleotide which operatively encodes for a foreign mimic of the tumor-associated antigen or a mutation of the self-antigen. The antigen-encoding polynucleotides are administered to host tissues which have a high concentration of antigen presenting cells in them relative to other host tissues. The method is particularly useful in treating cancer through induction of antigen-specific cytotoxic T lymphocytes in the host for lysis of tumor cells bearing the antigen. Devices and compositions for use in the methods of the invention are also described. |
申请公布号 |
AU4198196(A) |
申请公布日期 |
1996.05.31 |
申请号 |
AU19960041981 |
申请日期 |
1995.11.01 |
申请人 |
THE REGENTS OF THE UNIVERSITY OF CALIFORNIA |
发明人 |
DENNIS A. CARSON;EYAL RAZ |
分类号 |
C12N15/09;A61B17/20;A61K9/00;A61K9/08;A61K9/12;A61K31/07;A61K31/56;A61K31/59;A61K31/70;A61K31/7088;A61K38/00;A61K38/22;A61K39/00;A61K39/35;A61K48/00;A61N1/30;A61P35/00;A61P37/00;A61P37/04;A61P43/00;C07K14/11;C07K14/495;C07K14/54;C07K14/55;C07K14/705;C07K14/77;C07K16/00;C12N5/10;C12N15/00;C12N15/12;C12N15/87;C12R1/91;G01N33/50;G01N33/569;G01N33/574;G01N33/68 |
主分类号 |
C12N15/09 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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