发明名称 |
PROCESS FOR THE PRODUCTION OF SECONDARY METABOLITES |
摘要 |
The invention relates to an improved process for the production of a secondary metabolite comprising (i) fermentation of a microorganism capable of producing said secondary metabolite, and (ii) recovering said metabolite in substantially pure form. Said microorganism has been modified in a manner whereby the expression of one or more of the DNA sequences coding for (a) peptide(s), (a) protein(s) or (an) enzyme(s), involved in or interfering with the biosynthetic pathway of said secondary metabolite, is regulated differently from the regulation of said DNA sequence(s) in the orginal microorganism. Further contemplated is a process for production of said microorganism, a DNA construct, a vector or transformation vehicle, a microorganism capable of producing secondary metabolite and finally a secondary metabolite product. |
申请公布号 |
WO9610084(A1) |
申请公布日期 |
1996.04.04 |
申请号 |
WO1995DK00386 |
申请日期 |
1995.09.28 |
申请人 |
NOVO NORDISK A/S;EGEL-MITANI, MICHI;MOELLGAARD, HENRIK;KAASGAARD, SVEND;KRISTIANSEN, KLAUS, NYEGAARD |
发明人 |
EGEL-MITANI, MICHI;MOELLGAARD, HENRIK;KAASGAARD, SVEND;KRISTIANSEN, KLAUS, NYEGAARD |
分类号 |
C12N15/09;C12N1/15;C12N1/21;C12N9/00;C12N15/52;C12P1/00;C12P37/00;C12R1/80 |
主分类号 |
C12N15/09 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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