发明名称 |
Protease, reverse transcriptase and endonuclease of HIV-1 and RSV method for producing these enzymes |
摘要 |
Disclosed is a method for producing retroviral proteins which are protease, reverse transcriptase and endonuclease. The method is characterized by the consecutive expression and processing of retroviral genes by the stepwise cultivation of hosts transformed with a vector constructed to carry retroviral gene fragments comprising at least a protease gene and one or more of the other genes coding for retroviral proteins. The retroviral proteins of this invention are used as specific reagents for the diagnosis of retroviral disease, e.g., AIDS, malignant tumors and so forth, also may be used as the basis for research and development of antiviral agents and a vaccine against the above infectious diseases, and for genetic engineering.
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申请公布号 |
US5500355(A) |
申请公布日期 |
1996.03.19 |
申请号 |
US19930082505 |
申请日期 |
1993.06.25 |
申请人 |
THE RESEARCH FOUNDATION FOR MICROBIAL DISEASES OF OSAKA UNIVERSITY |
发明人 |
SAITO, ATSUSHI;SHINAGAWA, HIDEO;NAKATA, ATSUO |
分类号 |
C12N9/12;A61K39/00;C07K14/15;C07K14/16;C12N9/22;C12N9/50;C12N15/09;C12N15/57;(IPC1-7):C12P21/02;C12N15/48;C12N15/49;C12N15/70 |
主分类号 |
C12N9/12 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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