PROCESS FOR THE STEREOSELECTIVE REDUCTION OF STEROID ENELACTAMS
摘要
The novel process of this invention involves the reduction of certain DELTA -5 steroidal alkenes to selectively produce either the 5 alpha or 5 beta reduction products. Particularly, this invention involves reduction of DELTA -5 steroidal alkenes using a rhodium based catalyst in the presence of hydrogen to selectively yield 5 alpha steroids or alternatively reduction of DELTA -5 steroidal alkenes in an ionizing medium with a trialkylsilane to selectively yield 5 beta steroids.
申请公布号
WO9607643(A1)
申请公布日期
1996.03.14
申请号
WO1995US11355
申请日期
1995.09.05
申请人
MERCK & CO., INC.;HUMPHREY, GUY, R.;MILLER, ROSS, A.