NEW ARYLPIPERAZINE DERIVATIVES

摘要

The present invention relates to new compounds having general formula (I), wherein X is -(CH2)3-O-(CH2)4-; m equals 0 or 1, n equals 1, 2, 3 or 4; Ar is 1-naphthyl, 7-benzofuranyl, 2,3-dihydro-1,4-benzodioxane-5-yl, 3,4-dihydro-2H-1,5-benzodioxepin-6-yl, phenyl or phenyl substituted by alkyl, halogen, trifluoromethyl, nitro, cyano, alkoxy, amino, alkylcarbamyl, alkylsulfonamido or alkoxycarbonylo. The invention also relates to various alternative methods for the preparation of said compounds which present an affinity for the serotoninergic receptor 5-HT1A, which indicates their utility from the therapeutical point of view in the treatment of the CNS disorders such as anxiety and depression.